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Joined 1 year ago
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Cake day: June 11th, 2023

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  • Abstract

    Most of the widely used vaginal lubricants in the U.S. and Europe are strongly hyperosmolal, formulated with high concentrations of glycerol, propylene glycol, polyquaternary compounds or other ingredients that make these lubricants 4 to 30 times the osmolality of healthy vaginal fluid. Hyperosmolal formulations have been shown to cause marked toxicity to human colorectal epithelia in vivo, and significantly increase vaginal transmission of genital herpes infections in the mouse/HSV model. They also cause toxicity to explants of vaginal epithelia, to cultured vaginal epithelial cells, and increase susceptibility to HIV in target cells in cell cultures. Here, we report that the osmolality of healthy vaginal fluid is 370 ± 40 mOsm/Kg in women with Nugent scores 0–3, and that a well-characterized three-dimensional human vaginal epithelium tissue model demonstrated that vaginal lubricants with osmolality greater than 4 times that of vaginal fluid (>1500 mOsm/Kg) markedly reduce epithelial barrier properties and showed damage in tissue structure. Four out of four such lubricants caused disruption in the parabasal and basal layers of cells as observed by histological analysis and reduced barrier integrity as measured by trans-epithelial electrical resistance (TEER). No epithelial damage to these layers was observed for hypo- and iso-osmolal lubricants with osmolality of <400 mOsm/Kg. The results confirm extensive reports of safety concerns of hyperosmolal lubricants and suggest the usefulness of reconstructed in vitro vaginal tissue models for assessing safety of lubricants in the absence of direct clinical tests in humans.



  • Yes!

    My Xiaomi Redmi 11 keeps telling me the Calculator can’t use the network (why?) and keeps asking me to accept the privacy policy.

    Also the app wallpaper - the one that changes the locked screen background image (important complex stuff /s) - also keeps asking me to accept the privacy policy.

    And, as far as my reading of the policy goes, these privacy policies are just the one, it’s not a different one for each app.








  • What do you even mean with your word salad?

    Your first sentence/paragraph is absurd in the post’s context. Crop rotation will not replenish the soils’ potassium.

    And in your 2nd paragraph… what do you mean by “similar purpose”? It’s ambiguous, how you have used it. Also, do you know anything of how fertilizers work?

    Quick quiz: Wheat has b12 vitamin and iodine, can you just eat more bread to replenish your body’s neads for those nutrients? Or does a balanced diet need to be …balanced for all nutrients?