With all the hormones and whatnot inside. Dopamine, adrenaline, melatonin, whatever. Also, there’s this Hunter S. Thompson bit on the… pineal gland?
If it had an effect on you, wouldn’t it be a really messed up high, all over the place? With uppers, downers etc mixed? (Not including the emotional implications of eating raw human brains.)
I have a bevy of prior drug experience and still consider the way excess caffeine makes me feel to be what my idea of a mild high is.
The mind and body work hand in hand. Change one and the other feels it!