• ALoafOfBread@lemmy.ml
    link
    fedilink
    English
    arrow-up
    27
    ·
    15 hours ago

    If you have depression anxiety and find that Prozac (an ssri) doesnt work well, you might consider something that directly works on dopamine - like Buproprion (brand name = wellbutrin, a NDRI, norepinephrine dopamine reuptake inhibitor).

    • FiddlersViridian @sh.itjust.works
      link
      fedilink
      English
      arrow-up
      1
      ·
      38 minutes ago

      This is obviously anecdotal, but fuck Wellbutrin. It didn’t help, and it triggered tinnitus, which didn’t go away after I stopped taking it. Still happening 2 years later. I’m one of the lucky 3-6% Eeeeeeeeeeeeeeeeeeee

    • CompactFlax@discuss.tchncs.de
      link
      fedilink
      English
      arrow-up
      9
      ·
      14 hours ago

      I was a bit of not interested and not educated enough to know what a NDRI was while I was on it but it does make sense for ADHD and Depression symptoms.

      The withdrawal from Wellbutrin was bad. I got brain zaps if I was 1hr late taking it; tapering and cessation was miserable.

      • ALoafOfBread@lemmy.ml
        link
        fedilink
        English
        arrow-up
        2
        ·
        edit-2
        11 hours ago

        I have gone off a few times over the years and didn’t experience many side effects/withdrawals, but that is definitely not always the case - I’ve heard that it reeeaaally does not work for some people. Ymmv

        Similar to your comment about ADHD, I feel like it helps me with some of my autism symptoms (“low support needs”/aspergers)

      • PoliteDudeInTheMood@lemmy.ca
        link
        fedilink
        English
        arrow-up
        2
        ·
        1 hour ago

        I was on Effexor XR Max Dose, and one day when I realized that it had effectively killed all feelings I stopped cold turkey, zero side effects. My doctor thinks I have a very high drug tolerance, to the point that anything I’m put on nowadays is just started at close to the max dose. I’m on a drug right now that is prescribed at a level that would normally result in death for most people, and he thinks I can go higher if I need to.

        Downside is pain drugs don’t work, at all. He told me they’d need to give me IV pain meds if I really needed any pain suppression.