All 50 states as well as Washington, D.C., and four U.S. territories have agreed to sign a $7.4 billion settlement with the company and once-prominent family behind OxyContin, officials announced Monday.

The settlement resolves pending litigation against Purdue Pharma, which, under the leadership of the Sackler families, invented, manufactured and aggressively marketed opioid products for decades, according to the lawsuits. States and cities across the country said it fueled waves of addiction and overdose deaths.

The attorneys general in 55 states and territories have signed on to the historic settlement, which they said will end the Sacklers’ ownership of Purdue and bar them from making, selling or marketing opioids in the U.S.